Mots-C

Single vial or 10-vial kit

 MOTS-C Peptide – Research-Grade Mitochondrial Peptide

MOTS-C is a mitochondrial-derived peptide studied for its role in cellular energy regulation, metabolic signaling, and mitochondrial stress adaptation. Classified as a mitochondrial exercise-mimetic peptide, MOTS-C has gained significant attention in metabolic, aging, and endurance research models.

Royal Peptides supplies high-purity, third-party tested MOTS-C for laboratory research use only, with fast fulfillment from USA & Canada warehouses.

 What Is MOTS-C?

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded by mitochondrial DNA rather than nuclear DNA — a rare and unique characteristic.

In preclinical research, MOTS-C has been observed to:

• Activate AMP-activated protein kinase (AMPK)
• Influence mitochondrial stress signaling
• Support metabolic flexibility
• Act as an exercise-mimetic signal in cellular models

Unlike traditional peptides synthesized from nuclear genes, MOTS-C is part of a small class of mitochondrial-encoded peptides (MDPs), placing it at the center of advanced mitochondrial biology research.

 Mechanism of Action (Research Overview)

In laboratory studies, MOTS-C has demonstrated the ability to:

• Translocate to the nucleus under metabolic stress
• Activate AMPK pathways, which regulate energy homeostasis
• Modulate glucose and fatty acid metabolism in cell models
• Support mitochondrial adaptation signaling